Plaque reduction neutralization antibody test does not accurately predict protection against dengue infection in Ratchaburi cohort, Thailand

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Dengue Infection in Children in Ratchaburi, Thailand: A Cohort Study. II. Clinical Manifestations

BACKGROUND Dengue infection is one of the most important mosquito-borne diseases. More data regarding the disease burden and the prevalence of each clinical spectrum among symptomatic infections and the clinical manifestations are needed. This study aims to describe the incidence and clinical manifestations of symptomatic dengue infection in Thai children during 2006 through 2008. STUDY DESIG...

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Dengue Infection in Children in Ratchaburi, Thailand: A Cohort Study. I. Epidemiology of Symptomatic Acute Dengue Infection in Children, 2006–2009

BACKGROUND There is an urgent need to field test dengue vaccines to determine their role in the control of the disease. Our aims were to study dengue epidemiology and prepare the site for a dengue vaccine efficacy trial. METHODS AND FINDINGS We performed a prospective cohort study of children in primary schools in central Thailand from 2006 through 2009. We assessed the epidemiology of dengue...

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A plaque reduction test for dengue virus neutralizing antibodies.

The need for an efficient, practical, and accurate laboratory method for measuring dengue virus neutralizing antibody has been recognized by virologists concerned with arboviruses. Methods previously used include measurement of log neutralization indices by serial virus dilution tests with constant serum in suckling mice (1) or tissue culture tubes (2), or measurement of serum titers in sucklin...

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ژورنال

عنوان ژورنال: Virology Journal

سال: 2014

ISSN: 1743-422X

DOI: 10.1186/1743-422x-11-48